group network weight Physical Interactions Moutaoufik-Babu-2019 1.3E-3 Physical Interactions Pankow-Yates-2015 3.7E-4 Predicted I2D-IntAct-Mouse2Human 1.6E-3 Physical Interactions IREF-intcomplex 2.2E-3 Physical Interactions IREF-mppi 1.3E-3 Physical Interactions Jin-Pawson-2004 2.6E-4 Physical Interactions Mak-Moffat-2010 6E-3 Co-expression Dobbin-Giordano-2005 4.6E-3 Physical Interactions Liu-Wang-2012 2.2E-4 Physical Interactions Lee-Choi-2016 4.6E-3 Physical Interactions Coyaud-Raught-2015 4.2E-4 Physical Interactions McCracken-Blencowe-2005 1.2E-3 Physical Interactions Hu-Yin-2019 1.4E-3 Physical Interactions Giurato-Tarallo-2018 4.1E-4 Predicted I2D-Formstecher-Daviet-2005-Embryo-Fly2Human 2.6E-5 Co-expression Ramaswamy-Golub-2001 4.8E-3 Predicted I2D-MINT-Rat2Human 3.7E-4 Physical Interactions Bandyopadhyay-Ideker-2010 1.1E-3 Physical Interactions IREF-biogrid 1.2E-5 Physical Interactions Liu-Yang-2019 5.2E-4 Physical Interactions Choi-Beutler-2019 3.7E-4 Physical Interactions Drissi-Boisvert-2015 8.5E-4 Co-localization Zhang-Shang-2006 1.4E-2 Physical Interactions Floyd-Pagliarini-2016 1.4E-3 Physical Interactions Whisenant-Salomon-2015 1.4E-2 Physical Interactions Trepte-Wanker-2018 A 8.9E-4 Physical Interactions Tarallo-Weisz-2011 9.3E-4 Physical Interactions Devarajan-Ketha-Kumar-2012 1.9E-3 Predicted I2D-IntAct-Yeast2Human 8.2E-4 Physical Interactions Colicelli-2010 9.5E-3 Physical Interactions IREF-uniprotpp 1.4E-3 Physical Interactions Crow-Cristea-2017 1.2E-3 Physical Interactions Foerster-Ritter-2013 7.8E-4 Physical Interactions Giannone-Liu-2010 1.4E-3 Physical Interactions Chen-Ge-2013 B 6E-3 Physical Interactions Ertych-Bastians-2016 1.1E-2 Physical Interactions Malty-Babu-2017 8.8E-4 Physical Interactions McFarland-Nussbaum-2008 2.2E-2 Physical Interactions Li-Fu-2017 1.1E-2 Physical Interactions IREF-reactome 5.5E-3 Physical Interactions Wilkinson-Coba-2019 3.3E-4 Physical Interactions Douanne-Bidere-2019 9.2E-4 Co-expression Jiang-de Kok-2017 3.6E-3 Physical Interactions Li-Haura-2013 5.5E-4 Physical Interactions Banks-Washburn-2016 9.4E-4 Physical Interactions Lipp-Guthrie-2015 7.7E-4 Physical Interactions Cheng-DeCaprio-2017 1.5E-3 Co-expression Rieger-Chu-2004 4.5E-3 Physical Interactions Weinmann-Meister-2009 2.8E-3 Physical Interactions Kennedy-Kolch-2020 A 7.7E-4 Physical Interactions Scott-Schulman-2016 2.2E-3 Physical Interactions Wang-Yang-2011 1.9E-4 Co-expression Chen-Brown-2002 3.5E-3 Physical Interactions IREF-bind 5.9E-4 Physical Interactions Katsogiannou-Rocchi-2014 8.9E-4 Physical Interactions Abbasi-Schild-Poulter-2019 3.4E-4 Physical Interactions IREF-innatedb 1.3E-3 Co-expression Roth-Zlotnik-2006 5E-3 Physical Interactions Agrawal-Sedivy-2010 1.7E-3 Physical Interactions Nassa-Weisz-2019 2.9E-3 Physical Interactions Van Quickelberghe-Gevaert-2018 2.2E-3 Physical Interactions Rodriguez-von Kriegsheim-2016 2.4E-4 Physical Interactions Pao-Virdee-2018 1.1E-3 Physical Interactions Alsulami-Cagney-2019 3.4E-3 Physical Interactions Cao-Chinnaiyan-2014 9.9E-6 Physical Interactions Fonseca-Damgaard-2015 1.9E-3 Co-expression Alizadeh-Staudt-2000 4.6E-3 Physical Interactions Fragoza-Yu-2019 3.3E-5 Physical Interactions Wallach-Kramer-2013 1.4E-3 Physical Interactions Choudhury-Michlewski-2017 1.9E-3 Physical Interactions Liu-Varjosalo-2018 5E-3 Genetic Interactions Han-Bassik-2017 A 2.2E-3 Physical Interactions BIOGRID-SMALL-SCALE-STUDIES 1.4E-3 Physical Interactions Hosp-Selbach-2015 2.4E-3 Co-expression Perou-Botstein-1999 2.2E-3 Physical Interactions Zhang-Zou-2011 3.6E-4 Physical Interactions Rengasamy-Walsh-2017 4.1E-4 Physical Interactions Lee-Jeong-2017 1.7E-3 Physical Interactions Zhu-Liu-2018 1.3E-4 Physical Interactions Olma-Pintard-2009 1.3E-4 Physical Interactions Blomen-Brummelkamp-2015 5.5E-4 Physical Interactions Liu-Chen-2019 5.3E-4 Physical Interactions Yatim-Benkirane-2012 6E-3 Physical Interactions Li-Hung-2019 1.1E-2 Genetic Interactions Horlbeck-Gilbert-2018 B 1E-3 Physical Interactions Menon-Litovchick-2019 6.7E-4 Physical Interactions Mohammed-Carroll-2013 2.2E-3 Predicted I2D-Chen-Pawson-2009-PiwiScreen-Mouse2Human 5.7E-4 Co-expression Ross-Perou-2001 2.6E-3 Physical Interactions Fenner-Prehn-2010 3E-3 Physical Interactions IREF-matrixdb 4.3E-4 Physical Interactions Leung-Jones-2014 6.2E-3 Co-localization Chen-Huang-2014 3.7E-3 Physical Interactions Marechal-Zou-2014 1.5E-2 Physical Interactions Lee-Mayr-2019 1.7E-3 Physical Interactions Heidelberger-Beli-2018 4.1E-3 Physical Interactions Wang-Xiong-2019 1.1E-4 Physical Interactions Guardia-Laguarta-Przedborski-2019 1.7E-2 Physical Interactions Guard-Old-2019 4.2E-4 Physical Interactions Salvetti-Greco-2016 1.9E-3 Physical Interactions Kotlyar-Jurisica-2015 9.4E-3 Predicted I2D-Yu-Vidal-2008-GoldStd-Yeast2Human 1.2E-3 Physical Interactions Cox-Rizzino-2013 1.2E-3 Physical Interactions Behzadnia-Luhrmann-2007 2.7E-3 Physical Interactions Jones-MacBeath-2006 2.3E-3 Physical Interactions Chen-Guan-2018 3.1E-4 Physical Interactions Rivera-Paes Leme-2018 4E-4 Physical Interactions Teixeira-Laman-2016 A 4.2E-4 Genetic Interactions Du-Krogan-2017 1.1E-3 Physical Interactions Roy-Pardo-2014 1.5E-3 Pathway REACTOME 3.8E-3 Physical Interactions Kaltenbach-Hughes-2007 2E-3 Physical Interactions Rual-Vidal-2005 4.5E-4 Physical Interactions Saito-Kobarg-2017 7.1E-4 Physical Interactions Karblane-Sarmiento-2015 7.4E-4 Physical Interactions Wang-Huang-2017 4.4E-2 Physical Interactions Chen-Yu-2018 2.1E-4 Physical Interactions Persaud-Rotin-2009 B 2.9E-3 Physical Interactions Ahn-Lee-2008 5.6E-3 Physical Interactions Yao-Stagljar-2017 A 1.6E-3 Physical Interactions Oliviero-Cagney-2016 2.9E-3 Physical Interactions Hubel-Pichlmair-2019 1.9E-3 Predicted I2D-BioGRID-Fly2Human 8.6E-4 Physical Interactions Zeller-Wei-2006 4E-4 Physical Interactions IREF-huri 1.8E-4 Physical Interactions Kawahara-Paes Leme-2017 8.3E-5 Genetic Interactions Xiao-Brown-2018 5.9E-4 Physical Interactions Emdal-Olsen-2015 1.6E-3 Co-expression Innocenti-Brown-2011 4.6E-3 Physical Interactions Pladevall-Morera-Lopez-Contreras-2019 3.2E-3 Physical Interactions Cloutier-Coulombe-2017 3.2E-4 Physical Interactions Humphries-Humphries-2009 1.3E-3 Predicted I2D-Tarassov-PCA-Yeast2Human 2.9E-3 Pathway HUMANCYC 8.4E-5 Physical Interactions Petschnigg-Stagljar-2014 9.2E-3 Physical Interactions Woodsmith-Sanderson-2012 1.3E-3 Physical Interactions IREF-bhf-ucl 4.6E-3 Physical Interactions Scifo-Lalowski-2015 4.5E-3 Genetic Interactions BIOGRID-SMALL-SCALE-STUDIES 2.2E-3 Physical Interactions Narayan-Bennett-2012 1.2E-2 Physical Interactions Li-Dorf-2014 8.6E-4 Physical Interactions Diner-Cristea-2015 3.3E-3 Co-expression Wu-Garvey-2007 2.8E-3 Physical Interactions Guarani-Harper-2014 8.9E-3 Physical Interactions Xie-Zhang-2017 1.3E-4 Co-expression Boldrick-Relman-2002 3.9E-3 Physical Interactions Bett-Hay-2013 1.2E-3 Physical Interactions Barr-Knapp-2009 3.2E-3 Physical Interactions Hu-Woods-2019 2.1E-4 Physical Interactions Zhang-Xu-2018 7.1E-4 Physical Interactions Jang-Trono-2018 5.7E-3 Physical Interactions Rosenbluh-Hahn-2016 1.8E-3 Physical Interactions St-Denis-Gingras-2015 5.5E-4 Genetic Interactions Blomen-Brummelkamp-2015 9.3E-4 Predicted I2D-Li-Vidal-2004-CE-DATA-Worm2Human 7.3E-3 Pathway CELL_MAP 2.3E-3 Predicted I2D-BioGRID-Rat2Human 1.4E-3 Physical Interactions IREF-quickgo 2.2E-3 Physical Interactions Bogachek-Weigel-2014 1.2E-4 Physical Interactions Liu-Takahashi-2017 1.5E-3 Physical Interactions Loch-Strickler-2012 1.8E-3 Physical Interactions Roewenstrunk-de la Luna-2019 1.7E-3 Physical Interactions Lu-Bohr-2017 1.9E-3 Physical Interactions Wong-O'Bryan-2012 7.4E-4 Physical Interactions Kneissl-Grummt-2003 1.3E-2 Physical Interactions Koch-Hermeking-2007 4.5E-3 Physical Interactions Neganova-Lako-2011 4.2E-3 Physical Interactions Noguchi-Kawahara-2018 1.8E-3 Physical Interactions Miyamoto-Sato-Yanagawa-2010 9.5E-5 Physical Interactions Ewing-Figeys-2007 7E-4 Physical Interactions Wan-Emili-2015 2.1E-3 Physical Interactions Chen-Zhang-2013 4.3E-3 Physical Interactions Bennett-Harper-2010 1.3E-3 Physical Interactions St-Denis-Gingras-2016 1.2E-4 Physical Interactions Gilmore-Washburn-2016 1.8E-3 Physical Interactions Rowbotham-Mermoud-2011 1.8E-3 Physical Interactions Pichlmair-Superti-Furga-2012 1E-4 Physical Interactions Scholz-Taylor-2016 3.4E-4 Physical Interactions Tsai-Cristea-2012 1.3E-2 Pathway IMID 2.7E-3 Predicted I2D-Wang-Orkin-2006-EScmplxIP-Mouse2Human 1.8E-3 Physical Interactions Lim-Zoghbi-2006 2.7E-4 Physical Interactions Li-Zhou-2017 7.3E-4 Physical Interactions Reyniers-Taymans-2014 6.3E-4 Physical Interactions van Wijk-Timmers-2009 3.5E-4 Physical Interactions Boldt-Roepman-2016 1.2E-3 Genetic Interactions Achuthankutty-Mailand-2019 3.2E-4 Physical Interactions Kupka-Walczak-2016 7.5E-3 Physical Interactions Tang-Wang-2019 1.9E-3 Physical Interactions Berggard-James-2006 7.8E-3 Physical Interactions Matsumoto-Nakayama-2005 9.4E-3 Physical Interactions Yao-Stagljar-2017 B 4E-4 Genetic Interactions Shen-Mali-2017 3.2E-3 Physical Interactions Napolitano-Meroni-2011 9.9E-4 Predicted Stuart-Kim-2003 1.4E-3 Co-localization Johnson-Shoemaker-2003 7.1E-3 Predicted I2D-MGI-Mouse2Human 3.8E-4 Physical Interactions IREF-spike 2.3E-4 Physical Interactions McNamara-D'Orso-2016 3.8E-3 Physical Interactions Sahni-Vidal-2015 2.1E-5 Physical Interactions Christianson-Kopito-2011 8.6E-4 Physical Interactions Behrends-Harper-2010 8.6E-4 Physical Interactions Huttlin-Harper-2017 1E-3 Genetic Interactions Toyoshima-Grandori-2012 2.7E-3 Co-expression Wang-Maris-2006 6E-3 Physical Interactions Kumar-Vertegaal-2017 3.1E-4 Pathway NCI_NATURE 3.9E-3 Physical Interactions Campos-Reinberg-2015 8.8E-4 Physical Interactions Lum-Cristea-2018 1.4E-3 Physical Interactions Cai-Conaway-2007 1.7E-3 Co-expression Mallon-McKay-2013 5.1E-3 Physical Interactions Fogeron-Lange-2013 3.4E-3 Physical Interactions Gupta-Pelletier-2015 2E-3 Physical Interactions Choi-Busino-2018 1.4E-3 Physical Interactions Varjosalo-Superti-Furga-2013 9.9E-4 Physical Interactions Kim-Major-2015 5.9E-4 Genetic Interactions Lin-Smith-2010 8.6E-5 Predicted I2D-Krogan-Greenblatt-2006-NonCore-Yeast2Human 4.4E-4 Physical Interactions Taipale-Lindquist-2012 4.2E-3 Physical Interactions Vastrik-Stein-2007 5.5E-3 Physical Interactions Papp-Lamia-2015 1.5E-3 Physical Interactions Barrios-Rodiles-Wrana-2005 1.9E-3 Physical Interactions Raman-Harper-2015 8.1E-5 Physical Interactions Yang-Maurer-2018 2.2E-3 Physical Interactions Brehme-Superti-Furga-2009 2.3E-3 Physical Interactions Li-Dorf-2011 A 1.5E-3 Physical Interactions Perez-Hernandez-Yanez-Mo-2013 2.1E-4 Predicted I2D-BIND-Rat2Human 8.5E-4 Physical Interactions Yamauchi-Maeda-2018 9.3E-4 Physical Interactions Wu-Li-2007 1.4E-3 Physical Interactions Roy-Parent-2013 8.7E-4 Physical Interactions Zhang-Wheeler-2014 1.6E-3 Physical Interactions Zanon-Pichler-2013 5.9E-3 Physical Interactions Tiemann-Kani-2019 2.1E-3 Physical Interactions Varjosalo-Gstaiger-2013 A 1.9E-4 Physical Interactions Xu-Zetter-2016 2.2E-3 Physical Interactions Yachie-Roth-2016 1.6E-4 Physical Interactions Leung-Miller-2017 4.5E-3 Pathway Wu-Stein-2010 6E-3 Co-expression Perou-Botstein-2000 3.6E-3 Predicted I2D-BioGRID-Yeast2Human 7.1E-3 Physical Interactions Swayampakula-Dedhar-2017 2.3E-5 Physical Interactions Kahle-Zoghbi-2011 3.3E-4 Physical Interactions Taipale-Lindquist-2014 1.2E-4 Physical Interactions Olah-Ovadi-2011 1.7E-3 Physical Interactions Faust-Frankel-2018 3.2E-3 Physical Interactions Trepte-Wanker-2018 B 4.6E-4 Physical Interactions Xie-Cong-2013 3.8E-3 Physical Interactions Grossmann-Stelzl-2015 5.9E-4 Physical Interactions Moon-Kim-2014 1.8E-3 Predicted I2D-IntAct-Rat2Human 7.7E-4 Genetic Interactions Matsuoka-Elledge-2007 2.5E-3 Predicted I2D-Li-Vidal-2004-interolog-Worm2Human 5.1E-3 Physical Interactions Li-Lu-2018 9.6E-4 Physical Interactions IREF-corum 7.6E-4 Physical Interactions Meek-Piwnica-Worms-2004 1.4E-3 Physical Interactions Panigrahi-Pati-2012 9.2E-4 Physical Interactions Hein-Mann-2015 2.4E-3 Physical Interactions Wang-Xu-2015 7.1E-4 Physical Interactions Botham-Schimmer-2019 6E-4 Physical Interactions Yue-Liu-2018 1.6E-3 Physical Interactions Ouyang-Gill-2009 2.4E-5 Genetic Interactions Horlbeck-Gilbert-2018 A 1.1E-3 Physical Interactions Enzo-Dupont-2015 1E-3 Physical Interactions Beyer-Boldt-2018 3.4E-3 Predicted Wu-Stein-2010 2.4E-3 Predicted I2D-BIND-Mouse2Human 5.4E-4 Physical Interactions Zhou-Conrads-2004 3.8E-3 Physical Interactions Blandin-Richard-2013 5.4E-5 Physical Interactions Albers-Koegl-2005 2.4E-5 Physical Interactions Ravasi-Hayashizaki-2010 7.7E-5 Co-expression Wang-Cheung-2015 3.4E-3 Physical Interactions Asadi-Dhanvantari-2018 4.1E-4 Co-expression Burington-Shaughnessy-2008 4.4E-3 Physical Interactions Liebelt-Vertegaal-2020 1.8E-3 Physical Interactions Ramachandran-LaBaer-2004 1.5E-3 Physical Interactions Foster-Marshall-2013 2.7E-4 Physical Interactions Conte-Perez-Oliva-2018 4.6E-4 Physical Interactions Weishaupl-Schmidt-2019 2.6E-3 Physical Interactions Lau-Ronai-2012 8.8E-4 Physical Interactions Richter-Chrzanowska-Lightowlers-2010 1.1E-2 Physical Interactions Krl-Gorlich-2015 6.5E-3 Genetic Interactions Luo-Elledge-2009 2.6E-4 Physical Interactions Perez-Perri-Espinosa-2016 6.5E-3 Physical Interactions Dabbaghizadeh-Tanguay-2018 7.1E-4 Co-localization Schadt-Shoemaker-2004 1.1E-2 Physical Interactions Zhao-Krug-2005 1.1E-3 Physical Interactions Xu-Ye-2012 2.6E-4 Physical Interactions Freibaum-Taylor-2010 7.2E-3 Physical Interactions Lu-Zhang-2013 8.1E-3 Physical Interactions Liu-Tan-2018 4.4E-4 Physical Interactions Lleres-Lamond-2010 2.6E-3 Physical Interactions Viita-Vartiainen-2019 9.5E-4 Physical Interactions Joshi-Cristea-2013 9.1E-4 Physical Interactions Yu-Chow-2013 1E-2 Physical Interactions Greco-Cristea-2011 2.4E-3 Physical Interactions Hayes-Urbe-2012 6.5E-4 Shared protein domains PFAM 2.1E-3 Physical Interactions Singh-Moore-2012 1.4E-2 Physical Interactions Arroyo-Aloy-2014 1.2E-3 Physical Interactions IREF-bind-translation 6.7E-4 Physical Interactions Bantscheff-Drewes-2011 4.1E-4 Physical Interactions Tong-Moran-2014 1.6E-3 Physical Interactions Chi-Reed-2018 9.7E-4 Genetic Interactions Vizeacoumar-Moffat-2013 2.5E-3 Genetic Interactions Srivas-Ideker-2016 2.3E-3 Physical Interactions Woods-Monteiro-2012 B 3.2E-4 Physical Interactions Kristensen-Foster-2012 2.8E-3 Physical Interactions Huttenhain-Krogan-2019 4.6E-3 Predicted I2D-vonMering-Bork-2002-Low-Yeast2Human 1.8E-3 Predicted I2D-Krogan-Greenblatt-2006-Core-Yeast2Human 9.9E-4 Physical Interactions Soler-Lopez-Aloy-2011 2.4E-4 Physical Interactions IREF-mint 7.7E-4 Physical Interactions Yang-Brasier-2015 2.8E-3 Physical Interactions Low-Heck-2014 1.5E-3 Physical Interactions Havugimana-Emili-2012 2E-3 Physical Interactions Mugabo-Lim-2018 1.7E-3 Genetic Interactions Willingham-Muchowski-2003 5.9E-4 Physical Interactions Gloeckner-Ueffing-2007 2.3E-3 Physical Interactions Hegele-Stelzl-2012 B 4.7E-4 Physical Interactions Persaud-Rotin-2009 A 3.9E-3 Physical Interactions Oliviero-Cagney-2015 5.2E-4 Predicted I2D-BioGRID-Mouse2Human 1.4E-3 Physical Interactions Yang-Wang-2018 2.1E-3 Shared protein domains INTERPRO 3.9E-3 Physical Interactions Alexander-Wang-2018 1.2E-3 Physical Interactions Wang-Liu-2019 4.8E-3 Physical Interactions Huber-Hoelz-2017 4.2E-4 Co-expression Arijs-Rutgeerts-2009 3.9E-3 Physical Interactions Herr-Helleday-2015 2E-3 Physical Interactions Hauri-Beisel-2016 7.1E-4 Physical Interactions Sowa-Harper-2009 1.3E-3 Genetic Interactions Han-Bassik-2017 B 6.8E-4 Physical Interactions Shami Shah-Baskin-2019 1.6E-3 Physical Interactions Pichlmair-Superti-Furga-2011 3.3E-4 Physical Interactions Liu-Sun-2019 3.2E-5 Predicted I2D-vonMering-Bork-2002-Medium-Yeast2Human 4E-3 Predicted I2D-BIND-Yeast2Human 9.4E-5 Physical Interactions IREF-dip 2.1E-3 Physical Interactions IREF-hpidb 3.3E-3 Physical Interactions Thompson-Luchansky-2014 2.4E-3 Physical Interactions Keller-Lee-2014 2.9E-3 Physical Interactions Li-Wang-2016 7.3E-5 Physical Interactions Xiao-Lefkowitz-2007 2.4E-3 Physical Interactions Huttlin-Gygi-2015 5.1E-4 Physical Interactions Raisner-Gascoigne-2018 5.7E-3 Genetic Interactions Xie-Green-2012 2.3E-3 Physical Interactions Lee-Jou-2019 9.8E-3 Physical Interactions Woods-Monteiro-2012 A 1.8E-3 Physical Interactions Jeronimo-Coulombe-2007 1.9E-3 Physical Interactions Phillips-Corn-2013 3.3E-3 Predicted I2D-BIND-Worm2Human 2.3E-4 Physical Interactions Bouwmeester-Superti-Furga-2004 5.6E-4 Physical Interactions IREF-mbinfo 2.1E-3 Genetic Interactions IREF-SMALL-SCALE-STUDIES 2.2E-3 Physical Interactions Watanabe-Fujita-2018 4.9E-4 Physical Interactions Malinova-Verheggen-2017 1.9E-3 Physical Interactions Hutchins-Peters-2010 2.4E-3 Physical Interactions Elliott-Gyrd-Hansen-2016 4.7E-3 Physical Interactions Zhang-Vermeulen-2017 1.2E-2 Physical Interactions So-Colwill-2015 4.6E-4 Physical Interactions Kumar-Maddika-2017 7.7E-5 Co-expression Bild-Nevins-2006 B 4.4E-3 Physical Interactions Malovannaya-Qin-2010 3.2E-3 Predicted I2D-vonMering-Bork-2002-High-Yeast2Human 6E-3 Co-expression Rosenwald-Staudt-2001 2.8E-3 Predicted I2D-INNATEDB-Mouse2Human 1.5E-3 Physical Interactions Sundell-Ivarsson-2018 2.1E-4 Physical Interactions von Hundelshausen-Weber-2017 2.3E-2 Physical Interactions Varjosalo-Gstaiger-2013 B 2.5E-3 Physical Interactions Li-Chen-2015 7.7E-4 Physical Interactions Wang-Balch-2006 1.4E-3 Physical Interactions Jirawatnotai-Sicinski-2011 6.5E-3 Physical Interactions Murakawa-Landthaler-2015 4.7E-3