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Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Wang et al. (2006). Cancer Res.
Source: Pearson correlation with 231,830 interactions from GEO
Tags:
Multiclass cancer diagnosis using tumor gene expression signatures. Ramaswamy et al. (2001). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 226,615 interactions from supplementary material
Tags:
Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Radtke et al. (2009). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 377,767 interactions from GEO
Tags:
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. Gobble et al. (2011). Cancer Res.
Source: Pearson correlation with 449,507 interactions from GEO
Tags:
Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Kang et al. (2010). Blood.
Source: Pearson correlation with 549,783 interactions from GEO
Tags:
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. Hummel et al. (2006). N Engl J Med.
Source: Pearson correlation with 466,765 interactions from GEO
Tags:
Gene signatures of progression and metastasis in renal cell cancer. Jones et al. (2005). Clin Cancer Res.
Source: Pearson correlation with 365,428 interactions from GEO
Tags:
Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Bild et al. (2006). Nature.
Note: One of 3 datasets produced from this publication.
Source: Pearson correlation with 254,105 interactions from GEO
Tags:
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. Noble et al. (2008). Gut.
Source: Pearson correlation with 603,016 interactions from GEO
The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle. Wu et al. (2007). Endocrine.
Source: Pearson correlation with 223,988 interactions from GEO
Tags:
Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Nakayama et al. (2007). Mod Pathol.
Source: Pearson correlation with 361,398 interactions from GEO
Tags:
Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma. Burington et al. (2008). Clin Cancer Res.
Source: Pearson correlation with 266,464 interactions from GEO
Tags:
Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. Burczynski et al. (2006). J Mol Diagn.
Source: Pearson correlation with 419,356 interactions from GEO
Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults. Raue et al. (2012). J Appl Physiol.
Source: Pearson correlation with 483,849 interactions from GEO
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger et al. (2004). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 220,846 interactions from GEO
Tags:
Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. Arijs et al. (2009). PLoS One.
Source: Pearson correlation with 570,210 interactions from GEO
Tags:
Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. Peng et al. (2009). BMC Genomics.
Source: Pearson correlation with 349,954 interactions from GEO
Tags:
Gene expression changes in the course of normal brain aging are sexually dimorphic. Berchtold et al. (2008). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 507,933 interactions from GEO
Tags:
Gene expression profiling and response signatures associated with differential responses to infliximab treatment in ulcerative colitis. Toedter et al. (2011). Am J Gastroenterol.
Source: Pearson correlation with 572,082 interactions from GEO
Tags:
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Perou et al. (1999). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 50,804 interactions from supplementary material
Tags:
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Johnson et al. (2003). Science.
Source: Pearson correlation with 426,934 interactions from GEO
Tags:
A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Schadt et al. (2004). Genome Biol.
Note: Predicted transcript array
Source: Pearson correlation with 60,454 interactions from GEO
Source: Direct interaction with 171 interactions from iRefIndex
Source: Direct interaction with 345 interactions from BioGRID
A human functional protein interaction network and its application to cancer data analysis. Wu et al. (2010). Genome Biol.
Source: 78,448 interactions from supplementary material
Tags:
Source: Direct interaction with 24,924 interactions from Pathway Commons
Source: Direct interaction with 937 interactions from Pathway Commons
Source: Direct interaction with 10,118 interactions from Pathway Commons
Source: Direct interaction with 598 interactions from Pathway Commons
Source: Direct interaction with 685 interactions from Pathway Commons
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Behzadnia et al. (2007). EMBO J.
Source: Direct interaction with 101 interactions from iRefIndex
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl et al. (2003). J Mol Biol.
Source: Direct interaction with 83 interactions from iRefIndex
Tags:
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland et al. (2008). Mol Cell Proteomics.
Source: Direct interaction with 152 interactions from iRefIndex
Tags:
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins et al. (2010). Science.
Source: Direct interaction with 141 interactions from iRefIndex
Tags:
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo et al. (2007). Mol Cell.
Source: Direct interaction with 660 interactions from iRefIndex
Tags:
Self-assembling protein microarrays. Ramachandran et al. (2004). Science.
Source: Direct interaction with 119 interactions from iRefIndex
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault et al. (2009). Mol Cell Proteomics.
Source: Direct interaction with 242 interactions from iRefIndex
Tags:
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Sato et al. (2004). Mol Cell.
Source: Direct interaction with 235 interactions from iRefIndex
Tags:
Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr et al. (2009). Cell.
Source: Direct interaction with 177 interactions from iRefIndex
Source: Direct interaction with 385 interactions from iRefIndex
A quantitative protein interaction network for the ErbB receptors using protein microarrays. Jones et al. (2006). Nature.
Source: Direct interaction with 139 interactions from iRefIndex
Tags:
Defining the human deubiquitinating enzyme interaction landscape. Sowa et al. (2009). Cell.
Note: One of 2 datasets produced from this publication.
Source: Direct interaction with 1,511 interactions from BioGRID
Source: Direct interaction with 41,955 interactions from iRefIndex
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. Cannavo et al. (2007). J Biol Chem.
Source: Direct interaction with 109 interactions from iRefIndex
Tags:
Source: Direct interaction with 28,821 interactions from BioGRID
Source: Direct interaction with 12,700 interactions from iRefIndex
Source: Direct interaction with 5,310 interactions from iRefIndex
Source: Direct interaction with 637 interactions from iRefIndex
Source: Direct interaction with 21,448 interactions from iRefIndex
RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. de Hoog et al. (2004). Cell.
Source: Direct interaction with 220 interactions from iRefIndex
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen et al. (2009). Cell.
Source: Direct interaction with 233 interactions from iRefIndex
Tags:
Source: Direct interaction with 13,341 interactions from iRefIndex
An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter et al. (2009). Mol Syst Biol.
Source: Direct interaction with 307 interactions from iRefIndex
Tags:
High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles et al. (2005). Science.
Source: Direct interaction with 547 interactions from iRefIndex
Tags:
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Chen et al. (2009). Proc Natl Acad Sci U S A.
Note: I2D predictions of protein protein interactions using Chen-Pawson-2009 Mus musculus data
Source: Direct interaction with 30 interactions from I2D
A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science.
Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 567 interactions from I2D
BioGRID: a general repository for interaction datasets. Stark et al. (2006). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using BioGRID Saccharomyces cerevisiae data
Source: Direct interaction with 13,434 interactions from I2D
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature.
Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data
Source: Direct interaction with 1,196 interactions from I2D
A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science.
Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 15 interactions from I2D
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature.
Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data
Source: Direct interaction with 3,001 interactions from I2D
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature.
Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data
Source: Direct interaction with 16,074 interactions from I2D
A gene-coexpression network for global discovery of conserved genetic modules. Stuart et al. (2003). Science.
Source: 24,952 interactions from supplementary material
Tags:
High-quality binary protein interaction map of the yeast interactome network. Yu et al. (2008). Science.
Note: I2D predictions of protein protein interactions using Yu Gold Standard Saccharomyces cerevisiae data
Source: Direct interaction with 386 interactions from I2D
Tags:
The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using IntAct Rattus norvegicus data
Source: Direct interaction with 1,054 interactions from I2D
MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett.
Note: I2D predictions of protein protein interactions using MINT Mus musculus data
Source: Direct interaction with 977 interactions from I2D
MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett.
Note: I2D predictions of protein protein interactions using MINT Rattus norvegicus data
Source: Direct interaction with 574 interactions from I2D
The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using IntAct Mus musculus data
Source: Direct interaction with 3,422 interactions from I2D
BioGRID: a general repository for interaction datasets. Stark et al. (2006). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using BioGRID Mus musculus data
Source: Direct interaction with 288 interactions from I2D
Ontological visualization of protein-protein interactions. Drabkin et al. (2005). BMC Bioinformatics.
Note: I2D predictions of protein protein interactions using MGI Mus musculus data
Source: Direct interaction with 724 interactions from I2D
A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science.
Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 103 interactions from I2D
The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using IntAct Drosophila melanogaster data
Source: Direct interaction with 3,920 interactions from I2D
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Rattus norvegicus data
Source: Direct interaction with 556 interactions from I2D
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari et al. (2004). Mol Cell.
Note: I2D predictions of protein protein interactions usingTewari-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 18 interactions from I2D
Tags:
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Saccharomyces cerevisiae data
Source: Direct interaction with 1,543 interactions from I2D
MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett.
Note: I2D predictions of protein protein interactions using MINT Caenorhabditis elegans data
Source: Direct interaction with 1,166 interactions from I2D
InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Lynn et al. (2008). Mol Syst Biol.
Note: I2D predictions of protein protein interactions using INNATEDB Mus musculus data
Source: Direct interaction with 1,455 interactions from I2D
Tags:
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Caenorhabditis elegans data
Source: Direct interaction with 911 interactions from I2D
An in vivo map of the yeast protein interactome. Tarassov et al. (2008). Science.
Note: I2D predictions of protein protein interactions using Tarassov-Michnick-2008 Saccharomyces cerevisiae data
Source: Direct interaction with 441 interactions from I2D
Tags:
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Krogan et al. (2006). Nature.
Note: I2D predictions of protein protein interactions using Krogan-Greenblatt-2006 Saccharomyces cerevisiae data
Source: Direct interaction with 1,794 interactions from I2D
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Mus musculus data
Source: Direct interaction with 1,198 interactions from I2D
Source: Pearson correlation with 530,357 interactions from Pfam
Source: Pearson correlation with 488,822 interactions from InterPro
collagen, type IX, alpha 2 [Source:HGNC Symbol;Acc:2218]
Functions:
Synonyms: ENSG00000049089; ENSP00000361821; ENSP00000361834; ENSP00000388493; ENSP00000407377; 1298; COL9A2; NP_001843; NM_001852; DJ39G22.4; EDM2; STL5; CO9A2_HUMAN; Q14055;
More at Entrez
lecithin-cholesterol acyltransferase [Source:HGNC Symbol;Acc:6522]
Functions:
Synonyms: ENSG00000213398; ENSP00000264005; 3931; LCAT; NP_000220; NM_000229; LCAT_HUMAN; P04180;
More at Entrez
CDC42 effector protein (Rho GTPase binding) 4 [Source:HGNC Symbol;Acc:17147]
Functions:
Synonyms: ENSG00000179604; ENSP00000338258; ENSP00000404270; 23580; CDC42EP4; NP_036253; NM_012121; BORG4; KAIA1777; MGC17125; MGC3740; BORG4_HUMAN; Q9H3Q1;
More at Entrez
C1q and tumor necrosis factor related protein 2 [Source:HGNC Symbol;Acc:14325]
Functions:
Synonyms: ENSG00000145861; ENSP00000377545; 114898; C1QTNF2; NP_114114; NM_031908; CTRP2; zacrp2; C1QT2_HUMAN; Q9BXJ5;
More at Entrez
myelin associated glycoprotein [Source:HGNC Symbol;Acc:6783]
Functions:
Synonyms: ENSG00000105695; ENSP00000262624; ENSP00000355234; ENSP00000376048; ENSP00000440695; 4099; MAG; NP_001186145; NP_002352; NP_542167; NM_001199216; NM_002361; NM_080600; GMA; S-MAG; SIGLEC-4A; SIGLEC4A; MAG_HUMAN; P20916;
More at Entrez
MTERF domain containing 2 [Source:HGNC Symbol;Acc:28785]
Functions:
Synonyms: ENSG00000122085; ENSP00000241527; ENSP00000375840; ENSP00000384998; ENSP00000385183; ENSP00000385630; ENSP00000393063; ENSP00000401409; ENSP00000409023; ENSP00000413346; ENSP00000414989; ENSP00000419315; 130916; MTERFD2; NP_872307; NM_182501; NR_028049; NR_028050; NR_028051; MGC61716; MTER2_HUMAN; Q7Z6M4;
More at Entrez
interleukin 12 receptor, beta 1 [Source:HGNC Symbol;Acc:5971]
Functions:
Synonyms: ENSG00000096996; ENSP00000314425; ENSP00000403103; 3594; IL12RB1; NP_005526; NP_714912; NM_005535; NM_153701; CD212; IL-12R-BETA1; IL12RB; I12R1_HUMAN; P42701;
More at Entrez
kelch domain containing 7A [Source:HGNC Symbol;Acc:26791]
Functions:
Synonyms: ENSG00000179023; ENSP00000383505; ENSP00000439465; 127707; KLHDC7A; NP_689588; NM_152375; FLJ38753; RP11-422P22.2; KLD7A_HUMAN; Q5VTJ3;
More at Entrez
integrin, alpha D [Source:HGNC Symbol;Acc:6146]
Functions:
Synonyms: ENSG00000156886; ENSP00000323325; ENSP00000373854; ENSP00000394604; 3681; ITGAD; NP_005344; NM_005353; ADB2; CD11D; ITAD_HUMAN; Q13349;
More at Entrez
collagen, type IX, alpha 1 [Source:HGNC Symbol;Acc:2217]
Functions:
Synonyms: ENSG00000112280; ENSP00000315252; ENSP00000349790; ENSP00000359527; ENSP00000359530; 1297; COL9A1; NP_001842; NP_511040; NM_001851; NM_078485; DJ149L1.1.2; EDM6; STL4; CO9A1_HUMAN; P20849;
More at Entrez
collagen, type IX, alpha 3 [Source:HGNC Symbol;Acc:2219]
Functions:
Synonyms: ENSG00000092758; ENSP00000341640; ENSP00000394280; ENSP00000438537; 1299; COL9A3; NP_001844; NM_001853; DJ885L7.4.1; EDM3; FLJ90759; CO9A3_HUMAN; Q14050;
More at Entrez
collagen, type II, alpha 1 [Source:HGNC Symbol;Acc:2200]
Functions:
Synonyms: ENSG00000139219; ENSP00000338213; ENSP00000369889; ENSP00000378696; 1280; COL2A1; NP_001835; NP_149162; NM_001844; NM_033150; ANFH; AOM; COL11A3; SEDC; CO2A1_HUMAN; P02458;
More at Entrez
integrin, alpha X (complement component 3 receptor 4 subunit) [Source:HGNC Symbol;Acc:6152]
Functions:
Synonyms: ENSG00000140678; ENSP00000268296; 3687; ITGAX; NP_000878; NM_000887; CD11C; ITAX_HUMAN; P20702;
More at Entrez
zinc finger protein 621 [Source:HGNC Symbol;Acc:24787]
Functions:
Synonyms: ENSG00000172888; ENSP00000312144; ENSP00000340841; ENSP00000386051; ENSP00000408779; ENSP00000413236; 285268; ZNF621; NP_001091884; NP_940886; NM_001098414; NM_198484; FLJ45246; Q6ZSS3; ZN621_HUMAN;
More at Entrez
embryonal Fyn-associated substrate [Source:HGNC Symbol;Acc:16898]
Functions:
Synonyms: ENSG00000100842; ENSP00000216733; ENSP00000340607; ENSP00000416684; 10278; EFS; NP_005855; NP_115835; NM_005864; NM_032459; CAS3; CASS3; EFS1; EFS2; HEFS; EFS_HUMAN; O43281;
More at Entrez
BCL2-interacting killer (apoptosis-inducing) [Source:HGNC Symbol;Acc:1051]
Functions:
Synonyms: ENSG00000100290; ENSP00000216115; 638; BIK; NP_001188; NM_001197; BIP1; BP4; NBK; BIK_HUMAN; Q13323;
More at Entrez
fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:3688]
Functions:
Synonyms: ENSG00000077782; ENSP00000311337; ENSP00000322945; ENSP00000327229; ENSP00000337247; ENSP00000340636; ENSP00000348537; ENSP00000380280; ENSP00000380292; ENSP00000380297; ENSP00000380302; ENSP00000392645; ENSP00000393312; ENSP00000398318; ENSP00000400162; ENSP00000400708; ENSP00000432972; ENSP00000433163; ENSP00000433569; ENSP00000434473; ENSP00000434712; ENSP00000434800; ENSP00000434869; ENSP00000435254; ENSP00000435283; 2260; FGFR1; NP_001167534; NP_001167535; NP_001167536; NP_001167537; NP_001167538; NP_056934; NP_075593; NP_075594; NP_075598; NM_001174063; NM_001174064; NM_001174065; NM_001174066; NM_001174067; NM_015850; NM_023105; NM_023106; NM_023107; NM_023108; NM_023109; NM_023110; NM_023111; NM_032191; bFGF-R-1; BFGFR; CD331; CEK; FGFBR; FGFR-1; FLT-2; FLT2; HBGFR; KAL2; N-SAM; OGD; FGFR1_HUMAN; P11362;
More at Entrez
KIAA0195 [Source:HGNC Symbol;Acc:28983]
Functions:
Synonyms: ENSG00000177728; ENSP00000313885; ENSP00000364397; 9772; KIAA0195; NP_055553; NM_014738; TMEM94; K0195_HUMAN; Q12767;
More at Entrez
cytochrome P450, family 2, subfamily F, polypeptide 1 [Source:HGNC Symbol;Acc:2632]
Functions:
Synonyms: ENSG00000197446; ENSP00000333534; ENSP00000437320; ENSP00000443424; 1572; CYP2F1; NP_000765; NM_000774; C2F1; CYP2F; CP2F1_HUMAN; P24903;
More at Entrez
adenosine A2a receptor [Source:HGNC Symbol;Acc:263]
Functions:
Synonyms: ENSG00000128271; ENSP00000336630; ENSP00000394368; ENSP00000397071; ENSP00000400190; ENSP00000404497; ENSP00000414802; ENSP00000439848; 135; ADORA2A; NP_000666; NM_000675; hA2aR; RDC8; AA2AR_HUMAN; P29274;
More at Entrez
chimerin (chimaerin) 2 [Source:HGNC Symbol;Acc:1944]
Functions:
Synonyms: ENSG00000106069; ENSP00000222792; ENSP00000386849; ENSP00000386968; ENSP00000387425; ENSP00000394284; ENSP00000396867; ENSP00000398326; ENSP00000400282; ENSP00000406337; ENSP00000409843; ENSP00000438587; ENSP00000440526; ENSP00000441183; ENSP00000442812; ENSP00000444063; 1124; CHN2; NP_001035025; NP_004058; NM_001039936; NM_004067; ARHGAP3; CHN2-3; RHOGAP3; CHIO_HUMAN; P52757;
More at Entrez
| query genes | n/a | 1 / 1 |
| collagen | 4.6E-4 | 4 / 29 |
| extracellular matrix structural constituent | 4.81E-3 | 4 / 67 |
| extracellular matrix part | 4.81E-3 | 4 / 63 |
| proteinaceous extracellular matrix | 2.45E-2 | 4 / 108 |
| axon guidance | 5E-2 | 5 / 294 |
| extracellular matrix | 1.34E-1 | 4 / 184 |
3.1.1
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