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Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Wang et al. (2006). Cancer Res.
Source: Pearson correlation with 231,830 interactions from GEO
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Multiclass cancer diagnosis using tumor gene expression signatures. Ramaswamy et al. (2001). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 226,615 interactions from supplementary material
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Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Radtke et al. (2009). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 377,767 interactions from GEO
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Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. Gobble et al. (2011). Cancer Res.
Source: Pearson correlation with 449,507 interactions from GEO
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Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Kang et al. (2010). Blood.
Source: Pearson correlation with 549,783 interactions from GEO
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A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. Hummel et al. (2006). N Engl J Med.
Source: Pearson correlation with 466,765 interactions from GEO
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Gene signatures of progression and metastasis in renal cell cancer. Jones et al. (2005). Clin Cancer Res.
Source: Pearson correlation with 365,428 interactions from GEO
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Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Bild et al. (2006). Nature.
Note: One of 3 datasets produced from this publication.
Source: Pearson correlation with 254,105 interactions from GEO
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Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. Noble et al. (2008). Gut.
Source: Pearson correlation with 603,016 interactions from GEO
The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle. Wu et al. (2007). Endocrine.
Source: Pearson correlation with 223,988 interactions from GEO
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Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Nakayama et al. (2007). Mod Pathol.
Source: Pearson correlation with 361,398 interactions from GEO
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Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma. Burington et al. (2008). Clin Cancer Res.
Source: Pearson correlation with 266,464 interactions from GEO
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Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. Burczynski et al. (2006). J Mol Diagn.
Source: Pearson correlation with 419,356 interactions from GEO
Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults. Raue et al. (2012). J Appl Physiol.
Source: Pearson correlation with 483,849 interactions from GEO
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger et al. (2004). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 220,846 interactions from GEO
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Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. Arijs et al. (2009). PLoS One.
Source: Pearson correlation with 570,210 interactions from GEO
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Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. Peng et al. (2009). BMC Genomics.
Source: Pearson correlation with 349,954 interactions from GEO
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Gene expression changes in the course of normal brain aging are sexually dimorphic. Berchtold et al. (2008). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 507,933 interactions from GEO
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Gene expression profiling and response signatures associated with differential responses to infliximab treatment in ulcerative colitis. Toedter et al. (2011). Am J Gastroenterol.
Source: Pearson correlation with 572,082 interactions from GEO
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Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Perou et al. (1999). Proc Natl Acad Sci U S A.
Source: Pearson correlation with 50,804 interactions from supplementary material
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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Johnson et al. (2003). Science.
Source: Pearson correlation with 426,934 interactions from GEO
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A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Schadt et al. (2004). Genome Biol.
Note: Predicted transcript array
Source: Pearson correlation with 60,454 interactions from GEO
Source: Direct interaction with 171 interactions from iRefIndex
Source: Direct interaction with 345 interactions from BioGRID
A human functional protein interaction network and its application to cancer data analysis. Wu et al. (2010). Genome Biol.
Source: 78,448 interactions from supplementary material
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Source: Direct interaction with 24,924 interactions from Pathway Commons
Source: Direct interaction with 937 interactions from Pathway Commons
Source: Direct interaction with 10,118 interactions from Pathway Commons
Source: Direct interaction with 598 interactions from Pathway Commons
Source: Direct interaction with 685 interactions from Pathway Commons
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Behzadnia et al. (2007). EMBO J.
Source: Direct interaction with 101 interactions from iRefIndex
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl et al. (2003). J Mol Biol.
Source: Direct interaction with 83 interactions from iRefIndex
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Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland et al. (2008). Mol Cell Proteomics.
Source: Direct interaction with 152 interactions from iRefIndex
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Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins et al. (2010). Science.
Source: Direct interaction with 141 interactions from iRefIndex
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Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo et al. (2007). Mol Cell.
Source: Direct interaction with 660 interactions from iRefIndex
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Self-assembling protein microarrays. Ramachandran et al. (2004). Science.
Source: Direct interaction with 119 interactions from iRefIndex
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault et al. (2009). Mol Cell Proteomics.
Source: Direct interaction with 242 interactions from iRefIndex
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A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Sato et al. (2004). Mol Cell.
Source: Direct interaction with 235 interactions from iRefIndex
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Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr et al. (2009). Cell.
Source: Direct interaction with 177 interactions from iRefIndex
Source: Direct interaction with 385 interactions from iRefIndex
A quantitative protein interaction network for the ErbB receptors using protein microarrays. Jones et al. (2006). Nature.
Source: Direct interaction with 139 interactions from iRefIndex
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Defining the human deubiquitinating enzyme interaction landscape. Sowa et al. (2009). Cell.
Note: One of 2 datasets produced from this publication.
Source: Direct interaction with 1,511 interactions from BioGRID
Source: Direct interaction with 41,955 interactions from iRefIndex
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. Cannavo et al. (2007). J Biol Chem.
Source: Direct interaction with 109 interactions from iRefIndex
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Source: Direct interaction with 28,821 interactions from BioGRID
Source: Direct interaction with 12,700 interactions from iRefIndex
Source: Direct interaction with 5,310 interactions from iRefIndex
Source: Direct interaction with 637 interactions from iRefIndex
Source: Direct interaction with 21,448 interactions from iRefIndex
RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. de Hoog et al. (2004). Cell.
Source: Direct interaction with 220 interactions from iRefIndex
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen et al. (2009). Cell.
Source: Direct interaction with 233 interactions from iRefIndex
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Source: Direct interaction with 13,341 interactions from iRefIndex
An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter et al. (2009). Mol Syst Biol.
Source: Direct interaction with 307 interactions from iRefIndex
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High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles et al. (2005). Science.
Source: Direct interaction with 547 interactions from iRefIndex
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Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Chen et al. (2009). Proc Natl Acad Sci U S A.
Note: I2D predictions of protein protein interactions using Chen-Pawson-2009 Mus musculus data
Source: Direct interaction with 30 interactions from I2D
A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science.
Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 567 interactions from I2D
BioGRID: a general repository for interaction datasets. Stark et al. (2006). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using BioGRID Saccharomyces cerevisiae data
Source: Direct interaction with 13,434 interactions from I2D
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature.
Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data
Source: Direct interaction with 1,196 interactions from I2D
A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science.
Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 15 interactions from I2D
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature.
Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data
Source: Direct interaction with 3,001 interactions from I2D
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature.
Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data
Source: Direct interaction with 16,074 interactions from I2D
A gene-coexpression network for global discovery of conserved genetic modules. Stuart et al. (2003). Science.
Source: 24,952 interactions from supplementary material
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High-quality binary protein interaction map of the yeast interactome network. Yu et al. (2008). Science.
Note: I2D predictions of protein protein interactions using Yu Gold Standard Saccharomyces cerevisiae data
Source: Direct interaction with 386 interactions from I2D
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The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using IntAct Rattus norvegicus data
Source: Direct interaction with 1,054 interactions from I2D
MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett.
Note: I2D predictions of protein protein interactions using MINT Mus musculus data
Source: Direct interaction with 977 interactions from I2D
MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett.
Note: I2D predictions of protein protein interactions using MINT Rattus norvegicus data
Source: Direct interaction with 574 interactions from I2D
The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using IntAct Mus musculus data
Source: Direct interaction with 3,422 interactions from I2D
BioGRID: a general repository for interaction datasets. Stark et al. (2006). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using BioGRID Mus musculus data
Source: Direct interaction with 288 interactions from I2D
Ontological visualization of protein-protein interactions. Drabkin et al. (2005). BMC Bioinformatics.
Note: I2D predictions of protein protein interactions using MGI Mus musculus data
Source: Direct interaction with 724 interactions from I2D
A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science.
Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 103 interactions from I2D
The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res.
Note: I2D predictions of protein protein interactions using IntAct Drosophila melanogaster data
Source: Direct interaction with 3,920 interactions from I2D
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Rattus norvegicus data
Source: Direct interaction with 556 interactions from I2D
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari et al. (2004). Mol Cell.
Note: I2D predictions of protein protein interactions usingTewari-Vidal-2004 Caenorhabditis elegans data
Source: Direct interaction with 18 interactions from I2D
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BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Saccharomyces cerevisiae data
Source: Direct interaction with 1,543 interactions from I2D
MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett.
Note: I2D predictions of protein protein interactions using MINT Caenorhabditis elegans data
Source: Direct interaction with 1,166 interactions from I2D
InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Lynn et al. (2008). Mol Syst Biol.
Note: I2D predictions of protein protein interactions using INNATEDB Mus musculus data
Source: Direct interaction with 1,455 interactions from I2D
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BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Caenorhabditis elegans data
Source: Direct interaction with 911 interactions from I2D
An in vivo map of the yeast protein interactome. Tarassov et al. (2008). Science.
Note: I2D predictions of protein protein interactions using Tarassov-Michnick-2008 Saccharomyces cerevisiae data
Source: Direct interaction with 441 interactions from I2D
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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Krogan et al. (2006). Nature.
Note: I2D predictions of protein protein interactions using Krogan-Greenblatt-2006 Saccharomyces cerevisiae data
Source: Direct interaction with 1,794 interactions from I2D
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics.
Note: I2D predictions of protein protein interactions using BIND Mus musculus data
Source: Direct interaction with 1,198 interactions from I2D
Source: Pearson correlation with 530,357 interactions from Pfam
Source: Pearson correlation with 488,822 interactions from InterPro
purinergic receptor P2X, ligand-gated ion channel, 1 [Source:HGNC Symbol;Acc:8533]
Functions:
Synonyms: ENSG00000108405; ENSP00000225538; 5023; P2RX1; NP_002549; NM_002558; P2X1; P2RX1_HUMAN; P51575;
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purinergic receptor P2X, ligand-gated ion channel, 2 [Source:HGNC Symbol;Acc:15459]
Functions:
Synonyms: ENSG00000187848; ENSP00000341419; ENSP00000343339; ENSP00000343904; ENSP00000344502; ENSP00000345095; ENSP00000373762; ENSP00000405531; ENSP00000437646; ENSP00000444477; ENSP00000444853; 22953; P2RX2; NP_036358; NP_057402; NP_733782; NP_733783; NP_777361; NP_777362; NM_012226; NM_016318; NM_170682; NM_170683; NM_174872; NM_174873; P2X2; P2RX2_HUMAN; Q9UBL9;
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ryanodine receptor 2 (cardiac) [Source:HGNC Symbol;Acc:10484]
Functions:
Synonyms: ENSG00000198626; ENSP00000353174; ENSP00000355533; ENSP00000439181; ENSP00000440450; ENSP00000442743; ENSP00000443798; 6262; RYR2; NP_001026; NM_001035; ARVC2; ARVD2; RYR-2; VTSIP; Q92736; RYR2_HUMAN;
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ryanodine receptor 1 (skeletal) [Source:HGNC Symbol;Acc:10483]
Functions:
Synonyms: ENSG00000196218; ENSP00000347667; ENSP00000352608; ENSP00000354254; ENSP00000439627; 6261; RYR1; NP_000531; NP_001036188; NM_000540; NM_001042723; CCO; MHS; MHS1; RYDR; RYR-1; SKRR; P21817; RYR1_HUMAN;
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ryanodine receptor 3 [Source:HGNC Symbol;Acc:10485]
Functions:
Synonyms: ENSG00000198838; ENSP00000354735; ENSP00000373884; ENSP00000399610; 6263; RYR3; NP_001027; NP_001230925; NM_001036; NM_001243996; Q15413; RYR3_HUMAN;
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PYD and CARD domain containing [Source:HGNC Symbol;Acc:16608]
Functions:
Synonyms: ENSG00000103490; ENSP00000247470; ENSP00000340441; ENSP00000348263; 29108; PYCARD; NP_037390; NP_660183; NM_013258; NM_145182; NM_145183; CARD5; TMS1; ASC_HUMAN; Q9ULZ3;
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purinergic receptor P2X, ligand-gated ion channel, 4 [Source:HGNC Symbol;Acc:8535]
Functions:
Synonyms: ENSG00000135124; ENSP00000336607; ENSP00000353032; ENSP00000437396; ENSP00000438131; ENSP00000438329; ENSP00000439386; ENSP00000443115; ENSP00000444033; ENSP00000444274; 5025; P2RX4; NP_002551; NM_002560; NM_175567; NM_175568; P2X4; P2X4R; P2RX4_HUMAN; Q99571;
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purinergic receptor P2X, ligand-gated ion channel, 7 [Source:HGNC Symbol;Acc:8537]
Functions:
Synonyms: ENSG00000089041; ENSP00000261826; ENSP00000330696; ENSP00000366367; ENSP00000399864; ENSP00000437471; ENSP00000437729; ENSP00000438586; ENSP00000439247; ENSP00000439961; ENSP00000441230; ENSP00000442349; ENSP00000442470; ENSP00000442572; ENSP00000443640; ENSP00000445325; ENSP00000445564; 5027; P2RX7; NP_002553; NM_002562; NM_177427; NR_033948; NR_033949; NR_033950; NR_033951; NR_033952; NR_033953; NR_033954; NR_033955; NR_033956; MGC20089; P2X7; P2RX7_HUMAN; Q99572;
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chromosome 12 open reading frame 76 [Source:HGNC Symbol;Acc:33790]
Functions:
Synonyms: ENSG00000174456; ENSP00000308368; ENSP00000446788; ENSP00000447351; ENSP00000447574; ENSP00000448915; ENSP00000449939; ENSP00000450232; 400073; C12orf76; NP_997318; NM_207435; FLJ40142; CL076_HUMAN; Q8N812;
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purinergic receptor P2X, ligand-gated ion channel, 5 [Source:HGNC Symbol;Acc:8536]
Functions:
Synonyms: ENSG00000083454; ENSP00000225328; ENSP00000342161; ENSP00000415370; ENSP00000447545; ENSP00000447815; ENSP00000448355; ENSP00000449495; ENSP00000450006; 5026; P2RX5; NP_001191448; NP_001191449; NP_002552; NP_778255; NM_001204519; NM_001204520; NM_002561; NM_175080; NM_175081; P2X5; P2X5R; P2RX5_HUMAN; Q93086;
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purinergic receptor P2X, ligand-gated ion channel, 6 [Source:HGNC Symbol;Acc:8538]
Functions:
Synonyms: ENSG00000099957; ENSP00000338797; ENSP00000383997; ENSP00000385309; ENSP00000398347; ENSP00000401192; ENSP00000404223; ENSP00000407920; ENSP00000408088; ENSP00000416193; 9127; P2RX6; NP_001153026; NP_005437; NM_001159554; NM_005446; MGC129625; P2RXL1; P2X6; P2XM; O15547; P2RX6_HUMAN;
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neuropeptide FF-amide peptide precursor [Source:HGNC Symbol;Acc:7901]
Functions:
Synonyms: ENSG00000139574; ENSP00000267017; 8620; NPFF; NP_003708; NM_003717; FMRFAL; NPFF_HUMAN; O15130;
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purinergic receptor P2X, ligand-gated ion channel, 3 [Source:HGNC Symbol;Acc:8534]
Functions:
Synonyms: ENSG00000109991; ENSP00000263314; ENSP00000400118; ENSP00000434166; 5024; P2RX3; NP_002550; NM_002559; P2X3; P2RX3_HUMAN; P56373;
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prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [Source:HGNC Symbol;Acc:9604]
Functions:
Synonyms: ENSG00000095303; ENSP00000223423; ENSP00000354612; ENSP00000362802; ENSP00000411606; ENSP00000437709; 5742; PTGS1; NP_000953; NP_542158; NM_000962; NM_080591; PCOX1; PGHS-1; PGHS1; PHS1; PTGHS; P23219; PGH1_HUMAN;
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zona pellucida glycoprotein 2 (sperm receptor) [Source:HGNC Symbol;Acc:13188]
Functions: